Keyboard layout affects everything from desk space to workflow efficiency. Full-size keyboards (104 keys) include a numpad, essential for data entry professionals and accountants. Tenkeyless (TKL, 87 keys) removes the numpad for a more compact footprint while retaining function keys and navigation cluster. 75% layouts (84 keys) compress the function row and navigation keys into a tight, efficient arrangement popular among programmers and writers. 60% keyboards (61 keys) eliminate the function row and navigation cluster entirely, relying on layers for access to these keys, favored by minimalists and gamers who need maximum mouse space.